Apparently you haven't a clue about my level of education, intelligence or maturity and are willing to engage in snark and personal attacks - fair enough.
You played Rifts lol lol lol - how's that for mature?
You can not separate the two, knowledge is knowledge. Even if you think you are playing in character you still know the metagame stuff you are pretending not to know "in character" and that will inform your actions.
I have, many times. Many, many times. I have also run adventures set in whatever the OTU was at the time, CT every adventure, double adventure and boxed adventure, MT Knightfall and Flaming Eye, TNE every adventure, T4 every adventure. I used other rule systems to run some of those adventures, I ran bespoke setting galore.
I have tried to run T5, I have run MgT1e and 2e games, but I always go back to my homebrew CT mish mash of rules and my Long Night or Culture settings.
Which OTU do you mean? The Third Imperium? The Rebellion era? TNE, T4 and the early years of the Third Imperium?
And yet it happens, the setting says so. So somehwhere out there in the MgT OTU there a super powered characters...
Go and read what I said, slowly this time.
I said I like that the referee will get to decide the outcome, not that there is no setting. How do you have a FFW with no setting?