I certainly would like to see some "Core" world cyberpunk shenanigans. Having more cyberpunk in 2300 AD would be great. I normally keep the cyberpunk feel on Tirane and Earth, given the fact that both of them have extensive "Big Brother" security. Plus, with Transnats/Megacorps, the opportunity to make runs against them would be fun. In addition, Provolution activities would be great as well, as there is a large amount of plot possibilities there. I certainly would like seeing things not previously published, and a new campaign (for example, activities against the Provolution in an extended adventure/mini-campaign) developed. I would wage that a vast majority of the 2300AD players here are long time 2300AD players, and likely familiar with both Bayern and the Kafer Invasion.
Just my $0.02.
Oh, and the Pentapods are evil. I'm quite convinced of this.