Well, been running one set in a subsector of my own creation. First couple of sessions were getting the players used to the system, buying their ship, and then a couple quick passenger/trade runs.
Last night, I threw actual plot at them. They seemed to really enjoy it. Next game, two weeks from yesterday.
I've been using Google docs to track trade, subsector and planetary system information, ship information, and mortgage information which has made my note keeping much more organized. I was pleasently surprised by one of my players writing up full fledged Ship's Articles detailing crew responsibilities and other aspects.
So far, so good...