Personally, if you are going to do a "pure" cyberpunk game then there is very little space travel. Guns are (almost) entirely normal slug throwers. I would be quite hesitant to use powered armor in the setting either. A.I.s belong to the setting, obviously as well as hackers and ultimate bad ass killers for hire. Oh, did I mention the drugs and cybernetics?
For me the game (mainly Cyberpunk 2020) has always been a game about cybernetic urban mercenaries and I still like that aspect of the game although it would be nice to see other aspects supported in game mechanics (like Wildside did to Fixer).
Anyway, here's hopefully my cleaned list of what I would want included.
- Careers (hackers, middle men, gangers, suits, street ronin, etc.) that are modified (if needed) for the setting.
- Drugs - from recreational to various combat drugs etc.
- Augmentations (cybernetic but also biomods)
- Hacking rules that not only allow but preferably enforce the netrunner to go with the other team when on the job. I would like to see this role work quite a lot like various spell casters in fantasy games. Quite different from mundanes but can still work alongside the others. That is not so in many (older) cp games.
- Powered Armor or maybe up to a small mecha (like landmate)
- Variable power level like from gutterpunk up to a corporate scheming. From rusty old knife up to mecha with heavy weapons.
- I don't care whether the game has only firearms or also energy weapons (depends on how far to future it is set). If there are colonies in other parts of the solar system then energy weapons could work OK.
- Memes and other select parts of transhumanism but I don't want to go all the way to same direction as Transhuman Space or Eclipse Phase.
I hope it helps. BTW Takeshi Kovacs trilogy by Richard Morgan but also Mirrored Heavens and the sequels by David J. Williams are excellent sources for what I'd like to see. Yes, I know these are very different kinds of series and not all inclusive.