I can't see why one would want to. The apocalypse the PCs unleash on Charted Space isn't worth surviving.
I mean, I'm down for an epic level game and all, but player characters in control of massive amounts of functioning Ancients technology, along with the sponsorship of Yaskoydray or another Ancient, would utterly wreck the milieu. Don't get me wrong here... I'm not saying that 'your' players wouldn't act with restraint and due consideration for the consequences but we've all played and refereed groups that have no such limitations on their actions. And I don't trust my players with Battle Dress and FGMPs I'm sure as Hell not gonna give them TL 30 matter converters.
There is a great danger in post-apocalypse games in that they can easily degrade into an extended firefight over an unopened case of dog food. Unless the PCs are principled and wise, such an apocalypse is all too likely to happen.
I'm glad MJD explored the Ancients metagame to its 'unleash the hounds' end, but I really prefer a more restrained version of the Ancients where they remain mysterious and random. And I really try to limit the consequences of player error to something more manageable.
But then, YTUMV and all that.