Debris defence may have its work cut out for itself. The suicide ship has as much time to maneuver as it wants (one of the reasons I used a normal M-Drive rather than rockets), so you can't be totally sure of its vector. It doesn't *have* to accelerate all the while - that was just the simple case. The debris cloud is going to have to be quite dense and widespread to have any chance of an impact. I seriously doubt any normal sandcaster has the ability to do so with any realistic chance of a hit, though something mounted on a missile might have a shot.
Missiles may work, but are hampered by a lack of endurance. They won't be able to match velocities, so have to go for a frontal collision kill. Against a maneuvering target, that's going to be tough, and they only get one shot.
At several hundred km per second, you'll only have one space combat turn in which to engage it normally, with whatever systems you are using.
It's a tough proposition. Oh, and did I mention I'd expect these to be used in swarms?
Even a few hundred of them will be far cheaper to produce than a single major battleship. Or you could make 100 Dton ones that strike with a "mere" 15 Megaton impact...
Re smuggling in a nuke... you're probably right, though a special forces team dropping onto a planet probably requires more in money and risk terms for their stealth ship, special forces training and extraction (unless they are also on a suicide mission, in which case their training and equipment is not recovered).
Missiles may work, but are hampered by a lack of endurance. They won't be able to match velocities, so have to go for a frontal collision kill. Against a maneuvering target, that's going to be tough, and they only get one shot.
At several hundred km per second, you'll only have one space combat turn in which to engage it normally, with whatever systems you are using.
It's a tough proposition. Oh, and did I mention I'd expect these to be used in swarms?

Re smuggling in a nuke... you're probably right, though a special forces team dropping onto a planet probably requires more in money and risk terms for their stealth ship, special forces training and extraction (unless they are also on a suicide mission, in which case their training and equipment is not recovered).