A very AI heavy, transhumanist setting with extreme computerisation and old, old non-human past civilisations (not even close in nature to OTU "rubber suit" aliens). Jump gates and limited (but quick) routes.
...Well it all started off as a plot were the PCs were involved as assistants and security to an archaeological crew digging up a series of sites containing old relics belonging to a past alien civilisation (there are many given the universe is pretty old) on a holiday resort planet. Material dug up leads (of course) to all sorts of merry jinks and problems, as information later disclosed at the academic base seems to compromise all sorts of contemporaneous setting beliefs that other political entities currently hold dear... and thus that they want to shut down and silence (as if), with extreme prejudice (may or may not be true). Many complications, innocent bystanders, various leads to follow, kidnappings, places to go in order to find info... etc. etc..