I think you can mix in almost anything and it still being recognisably Traveller or even OTU. Anything that sticks to 1 week jump is pretty much there, giant robots or not.
I tend to emphasise more cybernetics and near AI stuff, routine genetic manipulation, less grav (I like wheels! and choppers!). More extinct civilisations - the Precursors - and the Ancients are not super-Droyne, and Grandfather does not, never did, exist (tho the Droyne are connected...). Oh, I also change any UWP that is impossible to one that is feasible, tho trying to keep the rest of it as close as poss with the published material.
I'd actually like to see a super high tech sourcebook. I tried running a campaign set in Bank's The Culture (based on Consider Phelbas), using Spacemaster at the time, but it became very hard to keep to with all the ultra-tech stuff. I ended up doing a version of a misjump and putting the PCs in the default Spacemaster setting (which was like a cross between the OTU and Dune). A companion tome dealing with how to run a super high tech campaign would be very useful.
Be even helpful for OTU games, as it'd help in the design of Ancient artefacts.