At 400 k/s you are about 1 hour from an Earth sized planet (starting from the 100 D area)... Plenty of time for the planetary based, Meson spinals to draw a real good bead
The same could be said of any forces approaching each other at any speed from a distance. Time to prepare.
The fleet intruders don't need constant thrust to maintain that 400 km/s. So their full thrust can be directed in any direction enroute and their effective velocity will still be pretty much the same. It is the same as a slower moving ship maneuvering to evade fire as it comes into range and attacks a target. The difference is that massive velocity difference takes the cruiser out of range within a turn while the slower moving ship will still need to maneuver and evade fire.
Meanwhile, a missile launched in advance of coming into range will be well ahead of the cruisers.
For example, a missile capable of 5G acceleration over 4 combat turns might be launched to travel for 45 minutes before coming into range of the defensive positions. These missiles would be travelling at 525 km/s and about 73 thousand km ahead of the cruisers. Unless intercepted they will hit the orbital facilities before the cruisers come into range. And since we are talking about missiles launched three turns before the cruisers have come into range, there should be at least two more volleys of missiles coming in behind them.
Orbital facilities will be particularly vulnerable as missiles coming in that fast may be very hard to intercept considering they are continuing to maneuver. They would be at a penalty to hit a ship that is maneuvering and would get just one chance to hit (it's speed is too great for it to come back and re-engage) but the same would apply when attacking the fleet intruders as they pass by. Proximity hits might be equally ineffective. You would need a direct hit.
To be clear. I wasn't claiming the enemy planetary defenses would have no means to attack. But they would be firing at a maneuvering ship that will probably have already launched its missiles and would be dedicating all its efforts to maneuver/evade and intercepting missiles coming in. The lightning class cruisers, capable of only 2G would likely have their fighters launched and screening the cruiser from missiles trying to intercept because they are particularly poor at maneuvering. But that said, they aren't stationary targets.
You may plot where it will be on its current vector, for example, but if it turns the direction of thrust 45 degrees to any side for 5 seconds, it will be 175 m to the side and about 75 m behind where it would have been if it had stayed on course. This is for a ship just 61.2 m wide. And that assumes it stays on a constant course for those five seconds.
Space is big and the cruisers would have the same defensive abilities as if they engaged the enemy craft/stations in regular combat. In Traveller space combat your speed doesn't make you any easier or harder to hit, it is the rate in which you are changing speed and direction (maneuvering). But an argument can be made that if you are crossing the entire range of an enemy's weapons in about 1/4 of a combat turn and are maneuvering such that the enemy cannot predict where you will be more than seconds in advance, there should be additional penalties to hit the cruisers. (and additional penalties if the cruisers want to try to fire their own spinal mounts on any enemy ship. It is all happening too fast.
Of course if you have missiles capable of holding off the initiation of their burn (and why not. any computer guidance system can be programmed). The cruisers could launch multiple waves of missiles that use slight amounts of burn to fan out around the cruiser and then hold off until a certain range to target. So if the cruiser has 24 missile bays firing 12 missiles per turn, there is no reason it couldn't assemble five turns of missiles in a spread around the cruiser waiting until 1,000,000 km from target to start accelerating to their targets. That's 1,440 missiles launched well outside of the 100D limit of the planet. The cruisers could have a jump plotted, decelerate to let the missiles get out of the way, and jump before they reach the planetary defenses. They never come into range, just the massive number of missiles they launched that are coming in at 500+ km/s. Nasty.