This ought to be a Spacequest sourcebook, and if the rights to Fallout are unavailable, a generic post-apocalyptic setting would be awesome.
I love Fallout, but the guys who try to set it to d20 are just wrong. SPECIAL is important to beardos like me who want all the familiar stuff from the franchise, but character classes? No. I liked that my skill dictated who I was in the world of Fallout and not my base attack progression. I think the (*)quest rules will probably be the best and closest fitting set of rules to SPECIAL without all of the complex computations that the computer can do.
Even without minis, I'd love a sourcebook that captured the humor and the brutality of the old games.