Thanks for the links, will investigate further! I did read the linked thread, but I'm not so much interested in a licensed version, just something I can use myself.
But reading through that thread, someone mentioned RuneQuest, and I have an inkling that it could be done that way too, with the emphasis on swordmasters and melee combat.
Hardest to work out will be matching up careers with Traveller career tables, particularly those with established hierarchies of training such as the Mentats and Bene Gesserit. The effects of drugs and mind techniques on aging and skill retention, etc...
I have the Dune Encyclopedia, and note also the myth/folk tale of MuaDib as a myth/fantasy story with aspects of magic in it. ie. stories from the Fremen's viewpoint, and I think a game from that perspective certainly should use RuneQuest.
I'll mull a little more on this.