A second for Mass Effect - that would be the best possible license for Traveller. ME has megacorps, aliens that are "alien" to about the same extent that OTU aliens are (physically different, some bizarre customs and weapons, but still relatable), a version of "psionics" (biotics) and that pseudo-hard science feel we all love.
The only problems I can imagine are not being able to come to a reasonable licensing fee with Bioware, since both companies (Mongoose and Bioware) will consider themselves the "primaries" in the license. In my experience, it's not easy to get pen&paper and video game companies to make deals.
Still, an official Mass Effect + Traveller source book would make me very, very happy. (I propose that it should be set before the events in the first game though, or depending on how the series ends up, a good bit afterwards. I'd like to have Geth around, and there is always some minor species like the Batarians causing trouble somewhere.)
Firefly is fun, but really not much of a stretch from standard Traveller. In fact, you'd be hard pressed to get a different setting if you rolled up your own subsector.
Brinn's "Uplift" setting fits nicely in a great many ways, and would be a nice change from the Humaniti-centered 3I.
The recent "John and Lobo" books by Mark Van Name has Traveller (well, more "Twilight Sector") written all over it. But it's not (yet) well known enough to be a real draw.