Sanctuary as Refuge fits into Glorantha perfectly. The Ilsigs are the Orlanthi, albeit Aeolian (but that better fits the more medieval imagery anyway), the god Ils suppressed by the Rankan Empire so after Heortland falls to the Lunars you have the new Lunar Governor "Prince Kadakithis" and his elite Lunar bodyguard, the Hell Hounds, etc.
The description of Refuge in the old Runequest Companion called it a Brithini outpost, which goes a long way to justifying the ancient, apparently immortal, sorcerers of great power and underground influence that populate Sanctuary.