I don´t see Dorastor as a good place for adventures in that period, except you want to kill you characters or drive them mad.
Remind me how that's any different to Third Age Dorastor?
To expand on Osentalka's post, the main differences
in the Second Age can be summed up as:
Obviously, there are no Lunars, no Lunar trade caravan and no Lunar forts. The Riskland Orlanthi settlements don't exist either.
There are no Greyskins, and no Mad Sultan.
The only Aldryami settlement is the Poisonthorn Elves. There are no Hellwood Elves yet.
The Telmori are newly settled in the land. They're still friends with the Poisonthorn Elves at this stage; later they will quarrel and fight.
Ralzakark is newly arrived in Dorastor, and is still establishing his power. He fought a war with the Elves at some stage and burned part of their forest. Note that so far, Ralzakark is unknown outside Dorastor - it's not until 1104 that he leads the first Chaos invasion of surrounding lands.
In general, Dorastor is less populated than in the Third Age, and largely a mystery to the surrounding peoples. It's regarded as a cursed, dead land - except for the travellers' tales that things
are stirring back to life there...