I would say it's very compatible with d20 modern. You might want to wait a few months for d20 Future. That would probably be a better fit. But you might need both books in addition to the main B5 d20 book.
Well, the only problem I see is the different way in which hit points are being treated in both. I've used the telepath class from B5 in d20 Modern: Agents of Psi games many times with a few tweaks.
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