Here's an interesting question - if Mongoose produces a second edition of the Traveller core rulebook should it place a greater emphasis on the OTU setting in the core rules or should it strive to be more of a generic SF ruleset?
My vote is very strongly for "generic". When I first encountered Traveller back in the 80s, what I loved most was the amount of setting- and campaign-generation baked into the rules. Ever since then, I've always used Traveller as a toolbox for building settings, regardless of whether it was for an actual Traveller game or not. Most of the tables and meta-game systems can be applied directly to any sci-fi game and they're not that difficult to adapt for fantasy or other genres.
Meanwhile, when I have played games using the full Traveller rules, the OTU setting has never interested me in the least. I'd much rather roll up a subsector (or sector) of my own and go from there without having to worry about what might be happening in the canon OTU timeline. (Not to mention that rolling my own also lets me get rid of the overarching Imperium, lower the average TL/population figures, etc. if I so choose.)