Basically much of the space related skills and manned positions come down to artificially required to make it a role playing game. Once the tech supports advanced enough programming you don't need Pilots, Gunners, Navigators and such. The issue then becomes one of inventing reasons why the game universe doesn't have fully automated space travel. Some options are...
Fire Control/5 versus a human with gunner(turrets)-1...
^^^^^^^^^^^^^^^^^^^^^Who are you calling HUMAN ya worthless tin can.
Hey I told everyone I was a ground forces grunt not a space marine and had no skill with ship weapons. It's hardly my fault we had no gunner, I was hired for security and Gorilla to man combat......
Anyway Computer controlled ships.
Processor failures, well with solid state and quantum computing these will be very rare and since your ship is going to be running a VI (Virtual Intelligence) council that basically votes on problems this allows them to identify any processor core that is doing something odd and shut it down.
A human ordering it to stop and be boarded. Please submit the one million digit identification code to allow for override of onboard computer control.
A computer controlled ship cannot defend itself from pirates. Hahahahahahahahaha. What is that computer program that fires the turrets on its own called again.
Unable to deal with on board problems that a human crew could. Repair drones, multiple processors running the top end programs and such like such a ship would be better than the average skill 1 crew at anything needed mid flight.
As I see it the limitations on computer controlled ships are not the computers. Instead it is going to be a case of the Humans not being happy with a tin can running the tin can.
Long boring cargo runs should be no problem, a team of Astrogators at each end of the run calculate the plots daily, the drone cargo ship uploads an up to date jump plot and away it goes.
It is going to be passenger ships that will have a living crew. Passengers being human, or at least alive, would for the most part prefer to know that people are in the loop. Much with the aircraft that these days can take off, fly the run and land without needing a human to touch the controls there are still pilots aboard to keep the passengers happy.
That isn't to say that computer controlled systems or even entire ships would not be around. A small craft without a gunner fits computer controlled turrets. A paranoid noble has his entire ships crew replaced with drones and only has his bodyguards on board.
The OTU is fairly anti AI and this would limit computer controlled ships a lot. Besides crew are cheap, it’s the space they take up that is expensive
Mega corps may well use them for dull cargo runs. They are perfect for x boats if the scouts run out of those loony x boat pilots. Long duration recon would also make sense with purely computer controlled scouts. A 100Dton drone that could jump somewhere, spend a year on station monitoring a system while powering itself with solar panels or very long duration cells then jump home. No crew to go made or need food.
In Terra/Sol given that the tech is overall higher and more widespread they would be very possible and many ships positions would likely be automated. However ships crew would be maintained for the same reason that the AI run factories have human support and supervisory staff. A shipping line would use human crew to gain access to the tax breaks for employing people rather than use purely computer controlled cargo ships. Passenger ships would be crewed for passenger comfort to keep everyone happy and occupied durring the jumps.
Given that multi week jumps are possible a lot of the ships crew on the bigger passenger ships are going to be there to look after the passengers not the crew.